5/27/2011

in alcoholic cirrhosis how and why are mallory bodies produced?

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in alcoholic cirrhosis how and why are mallory bodies produced?I'm having difficulty connecting alcoholic hepatitis and fibrosis leading to cirrhosis to the development of mallory bodies/hyalines. i know their collections of fibres in the liver cells but can't identify how they get produced, is it to do with the impairment of protein movements? also are they cytokeretin or collegen? if anyone can give me any help with this i would much appreciate it! any info on mallory bodies would be great.

Thanks kate x

jorge f
The precise mechanism of formation is not known (See Hepatology Research, October 2007 issue) but their chemical identity is hyperphosphorylated keratins 8 and 18.

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